Survival of LcS

Survival in the Gut

 

References

  1. Tuohy et al. (2007) Journal of Applied Microbiology 102(4):1026-1032.
  2. Mai et al. (2017) Asia Pacific Journal of Clinical Nutrition 26(1):72-77.
  3. Wang et al. (2015) Annals of Nutrition & Metabolism 67:257-266.
  4. Srinivasan et al. (2006) Journal Pediatric Gastroenterology and Nutrition 42:171-173.
  5. Lo Curto et al. (2011)  Food Microbiology 28:1359-1366.

Key Study

Survival of Lactobacillus casei Shirota through the gut – Tuohy et al. (2007) Journal of Applied Microbiology 102(4):1026-1032.

Method
This double-blind, placebo-controlled study at the University of Reading, involved 20 healthy volunteers who consumed either L. casei Shirota (at least 13×109 CFU) as a fermented milk drink or placebo for 21 days. Stool samples were collected at days 0, 7, 14, 21 and 28 to measure survival of L. casei Shirota and changes to faecal bacteria.  

Results
Seven days after subjects started to take the probiotic, L. casei Shirota was recovered at a mean level of 1.1 x 107 CFU/g of faeces, and this level was maintained throughout the course of probiotic consumption and decreased after participants stopped consuming the probiotic. Concurrently, in subjects consuming L. casei Shirota, an increase in total lactobacilli was observed, which persisted even after probiotic consumption had stopped. Bifidobacteria were also found to increase during the 21 days, but this increase was not sustained once consumption of L. casei Shirota had stopped.