There is a surprising and exciting breadth of research conducted with L. casei Shirota.
Studies include those conducted by researchers in the company’s research institutes in Japan and Belgium, as well as collaborative and independent research within hospitals, universities and institutes worldwide.
The effects of L. casei Shirota consumption have been investigated in several human studies, including those investigating the oral health of people with dentures (Sutula et al. 2012) and their own teeth (Sutula et al. 2013); the presence of Candida in the oral cavity of elderly people (Mendonça et al. 2013); the presence of Streptococcus mutans and cavities in children (Lin et al. 2014, Lin et al. 2017) and gingivitis (Slawik et al. 2011).
A study in 27 patients with lactose maldigestion and intolerance, found that a four-week intervention with a mixture of L. casei Shirota and B. breve Yakult reduced symptom scores and breath hydrogen after lactose ingestion (Almeida et al. 2012).
A double-blind, placebo controlled trial in 537 patients with knee osteoarthritis found that after 6 weeks of L. casei Shirota there was a significant improvement in quality of life (WOMAC) and pain (VAS) scores, as well as hs-CRP levels, compared to the placebo group (Lei et al. 2017)
In a double-blind placebo-controlled trial, 417 elderly patients with acute distal radius fractures were randomised to receive either L. casei Shirota or a placebo for 6 months. Throughout the intervention, several markers improved at a significantly faster rate in the probiotic group compared to placebo, including pain scores, range of motion and grip strength (Lei et al. 2016)