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Morimoto et al (2005) Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in smokers

Morimoto et al (2005) Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in smokers

Citation

Morimoto K, Takeshita T, Nanno M, Tokudome S, Nakayama K (2005) Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in smokers. Preventive Medicine 40: 589-594

Objective

To investigate whether consumption of a probiotic milk drink restores activity of natural killer (NK) cells in healthy people who habitually smoke.

Methods

In a double-blind, placebo-controlled trial, healthy smokers (n=99) were given an 80ml probiotic fermented milk drink containing 4 x 1010 Lactobacillus casei Shirota (LcS) or a placebo drink daily for three weeks. Before and after this intervention, peripheral blood mononuclear cells (PBMNC) were analysed for NK cell activity. A record was kept of the cigarettes each person smoked (average; number smoked before giving blood samples). These data were used to adjust the influence of smoking on NK cell activity

Results

An inverse correlation was found between the number of cigarettes smoked and individual NK cell activity. Average NK cell activity (after adjusting by the number of cigarettes smoked) was significantly higher in the probiotic group compared to the placebo group (P = 0.02). There was no difference in the total number of NK cells.

Conclusions

In habitual smokers, consumption of a probiotic fermented milk containing LcS restored NK cell activity, but not NK cell number.

 
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