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Lee LYW et al (2013) Prevention of relapse following Clostridium difficile infection using probiotic Lactobacillus casei Shirota.

Lee LYW et al (2013) Prevention of relapse following Clostridium difficile infection using probiotic Lactobacillus casei Shirota.

Citation

Lee LYW, Golmohamad R, MacFaul G (2013) Prevention of relapse following Clostridium difficile infection using probiotic Lactobacillus casei Shirota. International Journal of Probiotics & Prebiotics 8(4):145-148.

Objective

Recurrence rates of Clostridium difficile infection (CDI) are high: up to 35% of patients can have a relapse. The cost of treating patients is estimated as up to £11,000 per episode. This study examined the efficacy of the probiotic Lactobacillus casei Shirota in preventing recurrent episodes of CDI.

Methods

This single-site, cohort-controlled study in a UK hospital analysed follow up of 66 patients (median age 78 years) with CDI who, when first diagnosed, were treated with just antibiotics or antibiotics in combination with a probiotic fermented milk drink containing L. casei Shirota.

Results

Rates of CDI were significantly lower in the L. casei Shirota cohort (3.2%) compared to the cohort not given probiotic (20.0%; P=0.007).

Only six patients (19.4%) in the probiotic group required re-admission for diarrhoea within three months, compared to 13 patients (35.1%) in the control group not given the probiotic.

Conclusions

L. casei Shirota is associated with reduced C. difficile relapse rates.

 
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