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Martinez-Gomez et al (2009) Effect of Lactobacillus casei Shirota strain intraperitoneal administration in CD1 mice on the establishment of Trichinella spiralis adult worms and on IgA anti-T. spiralis production

Martinez-Gomez et al (2009) Effect of Lactobacillus casei Shirota strain intraperitoneal administration in CD1 mice on the establishment of Trichinella spiralis adult worms and on IgA anti-T. spiralis production

Citation

Martínez-Gómez F, Santiago-Rosales R, Bautista-Garfias CR (2009) Effect of Lactobacillus casei Shirota strain intraperitoneal administration in CD1 mice on the establishment of Trichinella spiralis adult worms and on IgA anti-T. spiralis production Veterinary Parasitology 162:171-175.

Objective

To determine whether administration of Lactobacillus casei Shirota (LcS) elicits an immune response against the parasitic nematode Trichinella spiralis.

[Explanatory note: trichinosis is a disease of cold and temperate regions caused by the larvae of the nematode worm T. spiralis. Trichinosis is contracted after eating undercooked meat infected with the larval cysts. Larvae released in the intestines penetrate the intestinal wall, causing diarrhoea and nausea, as well as fever, pain and other symptoms.] Lorem ipsum dolor sit amet, consectetur adipiscing elit. Aliquam nec ligula sit amet est dictum tincidunt. Morbi tempor ligula ut enim placerat facilisis id et sapien. Integer lorem quam, eleifend eget commodo sed, porttitor vitae metus. Donec eget est massa. Curabitur urna augue, dapibus a posuere semper, sagittis vel leo. Vivamus massa ligula, rutrum at dapibus vitae, viverra id lectus. In hac habitasse platea dictumst.

Methods

Mice (n=120) were inoculated by intraperitoneal route with  LcS (108 CFU) or phosphate buffered saline solution (control group) weekly for three weeks, and then given an oral challenge with larvae of T. spiralis strain ISS3. Anti-T. spiralis IgA concentrations were analysed from the challenged mice over a four week period. Six mice from each group were also investigated for the presence of adult worms.

Results

A significant difference in the presence of adult worms was identified between control and probiotic groups (P

Mice treated with LcS were found to have significantly higher concentrations of IgA in intestinal fluids than control mice (P

Conclusions

The probiotic LcS induced a protective effect in the mice against T. spiralis.  Administration of LcS was also associated with significantly higher production of anti-T. spiralis specific IgA.

 
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