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Banaszkiewicz A & Szajewska H (2005) Probiotics in the treatment of constipation: a systematic review of randomized controlled trials

Banaszkiewicz A & Szajewska H (2005) Probiotics in the treatment of constipation: a systematic review of randomized controlled trials

Citation

Banaszkiewicz A & Szajewska H (2005) Probiotics in the treatment of constipation: a systematic review of randomized controlled trials. Pediatria Wspolczesna 7(1):9-14

Objective

To systematically review randomised controlled trials of probiotics investigating constipation

Methods

Criteria for the review were randomised, double-blind trials with adults and children, comparing the efficacy of a probiotic with a placebo. The following databases were searched: MEDLINE (1966 – Jan 2004), EMBASE (1980 – Jan 2004), the Cochrane Central Register of Controlled Trials. Citations from studies and reviews were also checked

Results

The criteria resulted in selection of two studies involving a total of 140 subjects, which had used L. casei Shirota and E. coli Nissle. These strains had resulted in significant improvement in stool consistency. 

Conclusions

Due to the low number of trials that fitted the selection criteria, no generic conclusion on the efficacy of probiotics could be made. Large trials with clinical outcomes are still needed 

 
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